Life Synergy Retreat
Psilocybin wellness retreats in Playa del Carmen, Mexico
Life Synergy hosts guided psilocybin retreats for small groups of up to 11 adults in Playa del Carmen, Mexico. Over five days, an experienced team leads two facilitated ceremonies, yoga, breathwork and integration, with screening completed before any deposit. A wellness experience, not medical treatment.
- 2013founded
- 100+retreats hosted
- 500+guests welcomed
Why guests choose Life Synergy
Small, screened groups
About one team member for every three guests. Everyone completes health and medication questions and a screening call before being accepted.
Safety & screeningStructured ceremonies and integration
A nature ceremony and a temazcal ceremony, with preparation beforehand and facilitators present throughout each one. A one-to-one integration call after you return home is included.
Your five daysA named, experienced team
Founder and lead facilitator Juan Rendon works with Dr. Mauricio José Bussoli, MD, who supports the Day 1 medical Q&A and medication screening, and with temazcal, yoga, sound and cacao guides.
Meet the teamBeyond the ceremonies
The days around the ceremonies are built for rest, movement and reflection.
Guest reviews
What guests say
Excerpts from reviews posted on independent retreat platforms.
★★★★★
“The whole experience felt very safe, well-planned, and thoughtful. It is clear that Juan genuinely cares about the participants… The shamans that hosted us were kind, compassionate, and deeply committed… The experience was deeply meaningful in a lasting way.”
★★★★★
“My experience at the retreat was truly transformative. I feel much more relaxed, mindful, and intentional about not placing unnecessary stress and pressure on myself. Since attending, I have been more productive, more present in my daily life…”
★★★★★
“From the moment I spoke with Juan on the phone, I knew I was in good hands… EVERYTHING is taken care of — food, transport, accommodation — meaning I could just focus on making the most of my experience. Music and nature were the anchors of our ceremonies and our facilitators made us feel safe and supported at every stage of our personal journeys.”
Excerpts are quoted from public reviews and shortened where marked (…); minor typos corrected. Reviews describe personal experiences, which vary. They are not medical advice or a promise of any outcome.
Read all reviewsOther Life Synergy retreats
From the journal
Start here · The research
Psilocybin and the science of healing
A plain-language review of 42 studies: what psilocybin does in the brain, the depression and addiction trials, the mystical experience, safety and medications. By Juan Rendon · 35-minute read.
Read the reviewLatest articles
Psilocybin: A safer alternative to 21st century mood disorders
Anxiety and depression seem to be the epidemic of our time. Psilocybin as a promising alternative medicine for mental and spiritual health.
Nutrition Challenge: Take Back Your Health, and GET LIT!
Nutrition By Juan Rendon Updated October 2026 7 min read This nutrition challenge is about building an enjoyable, sustainable food routine with water, colorful produce, practical pantry staples, and satisfying meals. “GET LIT!” is an invitation to bring enthusiasm to...
From Ancient Rituals to Revolutionary Therapies
Trace sacred mushroom traditions, modern psilocybin research and the questions that connect history, cultural respect and a responsible retreat today.
Start with a discovery call
Talk with our team about dates, rooms and whether the retreat is right for you. We reply within one day.
Book a discovery callTaking medication? Tell us during screening, and never stop or change a prescription without guidance from your prescribing clinician. The retreat does not replace medical or psychiatric care.